Regulation of chromosome condensation

Across TCGA cell cohorts, RNA activity of the Regulation of chromosome condensation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAB2, EMC3, and UBE2L6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STAB2 grouped by Regulation of chromosome condensation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	STAB2 →	+0.383	+0.224	.004	.005	3	4
LUNG_NSCLC_LUSC	EMC3 →	+0.868	+0.228	.003	.007	2	5
BONE	UBE2L6 →	-2.627	-0.514	.002	.006	3	4
BONE	OXR1 →	+0.895	+0.293	.001	.003	3	4
CNS	TRIM23 →	+0.485	+0.188	<.001	.002	3	3
CNS	RGL4 →	+0.156	+0.268	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STAB2 by Regulation of chromosome condensation activity — CNS

Explore this box plot interactively →