Regulation of chromosome condensation

Across TCGA cell cohorts, RNA activity of the Regulation of chromosome condensation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RUVBL1, LMNB2, and HNRNPK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chromosome condensation activity versus RUVBL1 in PANCREAS (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RUVBL1 →	+1.330	+1.513	<.001	.001	3	8
PANCREAS	LMNB2 →	+1.382	+1.493	.003	<.001	3	7
BLOOD_Leukemia	HNRNPK →	+0.566	+0.259	<.001	.004	3	7
BLOOD_Leukemia	USP39 →	+0.635	+0.314	<.001	.001	3	7
BLOOD_Leukemia	RBMX →	+0.692	+0.318	<.001	<.001	3	7
BLOOD_Leukemia	RBM14 →	+0.629	+0.324	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060623 vs RUVBL1 — PANCREAS

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