Fat pad development

pathway activity — cross-omics
GO:0060613Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Fat pad development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRPK1, KANK2, and LAMA4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCASRPK1 →-0.268-0.049<.001<.00137
COADKANK2 →+0.681+0.040<.001<.00137
OVLAMA4 →+0.710+0.072<.001<.00137
BRCALARP4_S722 →-0.399-0.075<.001<.00137
BRCATLN2 →+0.477+0.065<.001<.00136
PDACVIM →+0.572+0.080<.001<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration