Mammary gland duct morphogenesis

Across TCGA cell cohorts, RNA activity of the Mammary gland duct morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDE1, SLC25A4, and PARD6G, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GDE1 grouped by Mammary gland duct morphogenesis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GDE1 →	+0.514	+1.082	.003	.005	3	4
LIVER	SLC25A4 →	+0.956	+1.423	.009	.006	3	4
LUNG_SCLC	PARD6G →	+1.479	+1.438	.002	<.001	3	4
OVARY	CCL5 →	-1.400	-1.332	.002	<.001	3	4
LUNG_SCLC	STRADA →	+0.565	+0.896	.006	.009	3	4
SKIN	DMTF1 →	+0.341	+0.945	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GDE1 by Mammary gland duct morphogenesis activity — LARGE_INTESTINE

Explore this box plot interactively →