Branch elongation of an epithelium

Across TCGA patient cohorts, RNA activity of the Branch elongation of an epithelium pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBM20, BOC, and MIR548L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Branch elongation of an epithelium activity versus RBM20 in OV (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RBM20 →	+0.469	+0.581	.003	<.001	3	4
HNSC	BOC →	+0.498	+0.578	.004	<.001	3	4
CCRCC	MIR548L →	+0.511	+0.499	.004	.003	2	5
LSCC	FLCN →	+0.235	+0.380	.004	.006	3	4
LSCC	CTLA4 →	-0.539	-0.607	.003	<.001	3	4
LSCC	FGFBP3 →	+0.316	+0.464	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060602 vs RBM20 — OV

Explore this scatter interactively →