Q-omics provides the consensus-scored MIR548L profile across patient tissues and cancer cell-line models. MIR548L expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, MIR548L is differentially expressed in 7, with the highest sampling consensus in HNSC. Additionally, MIR548L RNA expression shows 13,066 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight ACC, HNSC, and UVM as cancer lineages where MIR548L shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MIR548L — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MIR548L survival associations across molecular data types. MIR548L RNA expression shows survival associations in the most cancer types (20). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MIR548L RNA expression–survival associations across cancer types. High MIR548L expression shows unfavorable associations in ACC, READ, CHOL, UCEC, THYM and CESC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify ACC as the clearest survival context for MIR548L RNA expression.
This table summarizes MIR548L tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for MIR548L. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MIR548L shows lower tumor expression in BRCA and THCA and higher tumor expression in HNSC, LUSC, CHOL and ESCA. The HNSC box plot shows higher MIR548L RNA expression in tumor versus normal tissue (log2 FC = +0.272, t-test p < 0.001).
This table shows molecular features associated with MIR548L in patient tissues and cancer cell lines. In patient samples, MIR548L shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
