Multicellular organismal-level iron ion homeostasis

Across TCGA cell cohorts, RNA activity of the Multicellular organismal-level iron ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GGACT, RHOC, and SASH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GGACT grouped by Multicellular organismal-level iron ion homeostasis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GGACT →	-1.763	-1.640	.002	.001	3	5
BONE	RHOC →	-2.105	-1.155	.002	.006	3	5
KIDNEY	SASH1 →	+0.823	+0.946	.005	.001	3	4
KIDNEY	IKBIP →	-0.684	-0.941	.004	.001	3	4
BLOOD_Leukemia	VAMP4 →	-0.856	-0.359	.004	.003	3	4
CNS	DNMT3A →	+0.785	+1.074	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GGACT by Multicellular organismal-level iron ion homeostasis activity — SOFT_TISSUE

Explore this box plot interactively →