Cell fate commitment involved in pattern specification

Across TCGA cell cohorts, RNA activity of the Cell fate commitment involved in pattern specification pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL23, MFSD9, and FKBP14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MRPL23 grouped by Cell fate commitment involved in pattern specification-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MRPL23 →	-0.544	-0.874	.007	.003	3	6
LARGE_INTESTINE	MFSD9 →	+0.458	+0.805	.006	.005	3	4
LUNG_NSCLC_LUAD	FKBP14 →	+0.523	+0.897	.006	.001	3	4
BONE	MTSS1 →	+2.710	+1.741	.002	<.001	3	4
LIVER	SIX1 →	-1.061	-1.214	.004	.002	3	4
LIVER	FGF2 →	-2.753	-1.489	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MRPL23 by Cell fate commitment involved in pattern specification activity — PANCREAS

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