Intestinal epithelial cell development

Across TCGA patient cohorts, RNA activity of the Intestinal epithelial cell development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP2K3, CAMK1D, and OMD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestinal epithelial cell development activity versus MAP2K3 in GBM (Pearson r = 0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAP2K3 →	+0.276	+0.051	<.001	<.001	3	5
HNSC	CAMK1D →	-0.252	-0.065	<.001	<.001	3	4
HNSC	OMD →	-0.938	-0.065	.008	.006	3	4
GBM	PPCS →	+0.322	+0.047	<.001	.001	3	4
OV	ASRGL1 →	+0.824	+0.050	.002	.001	3	4
COAD	GCA →	+0.575	+0.037	.005	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060576 vs MAP2K3 — GBM

Explore this scatter interactively →