Intestinal epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the Intestinal epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SASH1, NOP56P3, and RN7SL677P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestinal epithelial cell differentiation activity versus SASH1 in CCRCC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SASH1 →	+0.361	+0.394	.003	.001	3	3
UCEC	NOP56P3 →	+1.168	+0.641	<.001	.003	3	3
LUAD	RN7SL677P →	+0.692	+0.603	.004	<.001	3	3
GBM	MANBAL →	+0.269	+0.144	<.001	.001	3	2
GBM	SLC39A7 →	+0.180	+0.100	.009	.003	3	2
GBM	DDX27 →	+0.191	+0.108	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060575 vs SASH1 — CCRCC

Explore this scatter interactively →