Intestinal epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Intestinal epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOPBP1, HAUS8, and AIF1L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TOPBP1 grouped by Intestinal epithelial cell differentiation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TOPBP1 →	-0.863	-1.200	.002	<.001	3	5
CNS	HAUS8 →	-0.696	-0.933	.009	.005	3	4
STOMACH	AIF1L →	-2.708	-1.171	.002	.003	3	4
LUNG_NSCLC_LUSC	C5 →	-1.100	-1.583	<.001	<.001	3	4
LUNG_NSCLC_LUSC	ARL3 →	-1.028	-1.570	<.001	<.001	3	4
LUNG_NSCLC_LUSC	CEP19 →	-1.301	-1.107	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TOPBP1 by Intestinal epithelial cell differentiation activity — LUNG_SCLC

Explore this box plot interactively →