Neuroepithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Neuroepithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL2BP, SERPINE2, and NAPA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuroepithelial cell differentiation activity versus ARL2BP in BONE (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ARL2BP →	+1.313	+0.213	.001	.001	3	5
OVARY	SERPINE2 →	+2.873	+0.156	.003	.005	2	6
LUNG_NSCLC_LUSC	NAPA →	+1.170	+0.375	.003	<.001	3	5
BONE	ZEB1 →	+2.541	+0.253	<.001	<.001	3	4
SOFT_TISSUE	C5orf34 →	+0.665	+0.111	.006	.005	2	5
BONE	TBC1D19 →	+1.460	+0.216	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060563 vs ARL2BP — BONE

Explore this scatter interactively →