Developmental growth involved in morphogenesis

Across TCGA patient cohorts, RNA activity of the Developmental growth involved in morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCL1A, SFRP1, and HAS1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Developmental growth involved in morphogenesis activity versus TCL1A in COAD (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TCL1A →	+1.333	+1.913	.002	<.001	3	1
COAD	SFRP1 →	+3.363	+1.863	.002	<.001	3	1
COAD	HAS1 →	+1.069	+1.913	.009	<.001	3	1
COAD	CCDC6 →	-0.735	-2.060	.005	.003	3	1
COAD	MSH3 →	-0.703	-1.913	.002	<.001	3	1
COAD	SMG7 →	-1.280	-1.873	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060560 vs TCL1A — COAD

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