Developmental growth involved in morphogenesis

Across TCGA cell cohorts, RNA activity of the Developmental growth involved in morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBI, ALCAM, and CPNE1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Developmental growth involved in morphogenesis activity versus TGFBI in BONE (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TGFBI →	+5.083	+0.247	.003	.004	3	7
SOFT_TISSUE	ALCAM →	+2.788	+0.923	.005	.006	1	8
BREAST	CPNE1 →	+1.049	+0.583	<.001	.006	3	6
LUNG_NSCLC_LUSC	DHODH →	-1.227	-0.260	<.001	<.001	3	6
BONE	ATP5F1B →	-0.766	-0.368	.009	<.001	3	5
STOMACH	WDR43 →	-0.685	-0.421	.005	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060560 vs TGFBI — BONE

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