Positive regulation of necroptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of necroptotic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM171A2, MKS1, and ATCAY, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of necroptotic process activity versus FAM171A2 in GBM (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FAM171A2 →	-1.056	-0.596	<.001	.003	3	4
LSCC	MKS1 →	-0.343	-0.374	.002	.001	3	4
GBM	ATCAY →	-2.290	-0.756	<.001	<.001	3	4
GBM	UBXN2A →	-0.362	-0.761	.002	<.001	3	4
LSCC	RPL23A →	-0.457	-0.322	<.001	<.001	3	4
GBM	PIP4K2B →	-0.541	-0.676	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060545 vs FAM171A2 — GBM

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