Prostate glandular acinus morphogenesis

pathway activity — cross-omics
GO:0060526Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Prostate glandular acinus morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS1, POLR1E, and CCNYL1_S344, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCASORBS1 →+0.628+0.116<.001<.00136
BRCAPOLR1E →-0.346-0.092<.001<.00135
BRCACCNYL1_S344 →-0.455-0.138.001<.00135
UCECPBX1 →+0.491+0.146<.001<.00135
UCECAASS →+0.521+0.140<.001<.00135
BRCAUBA1_S835 →-0.685-0.099<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration