Prostate glandular acinus morphogenesis

pathway activity — cross-omics
GO:0060526Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Prostate glandular acinus morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRANCR, ANKRD29, and UBE2C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADPRANCR →+0.190+0.177<.001.00934
LUADANKRD29 →+0.955+0.240.002.00234
LUADUBE2C →-1.064-0.190.004.00734
LSCCRIMS4 →+0.750+0.192.009.00834
LSCCSFRP1 →+2.095+0.344<.001<.00134
BRCAMIS18A →-0.420-0.521.001.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration