Prostate gland morphogenesis

Across TCGA cell cohorts, RNA activity of the Prostate gland morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF9, CXADR, and PRAG1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IRF9 grouped by Prostate gland morphogenesis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IRF9 →	-0.172	-0.163	.003	.003	3	4
CNS	CXADR →	+0.136	+0.322	<.001	.003	3	4
OESOPHAGUS	PRAG1 →	-0.122	-0.242	.004	<.001	3	4
LUNG_NSCLC_LUAD	RHOG →	-0.111	-0.670	.004	.001	3	4
SKIN	MYBL2 →	+0.215	+0.736	.002	.007	3	4
KIDNEY	LRRC15 →	-0.168	-0.831	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IRF9 by Prostate gland morphogenesis activity — BREAST

Explore this box plot interactively →