Epithelial cell proliferation involved in lung morphogenesis

pathway activity — cross-omics
GO:0060502Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Epithelial cell proliferation involved in lung morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NFIB_S328, SPINDOC_S152, and ZNF687_T191, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMNFIB_S328 →+0.530+0.295<.001<.00134
UCECSPINDOC_S152 →+1.342+0.679.002.00124
BRCAZNF687_T191 →+0.873+0.426<.001.00133
OVCLASRP_S294 →+0.608+0.170<.001<.00133
GBMNFIB →+0.487+0.272<.001<.00133
GBMARID1A →+0.256+0.323<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration