Acrosomal vesicle exocytosis

Across TCGA patient cohorts, RNA activity of the Acrosomal vesicle exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSP90AA1_S231, ATP6V0A1, and MCRIP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acrosomal vesicle exocytosis activity versus HSP90AA1_S231 in LSCC (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HSP90AA1_S231 →	+0.249	+0.073	<.001	<.001	3	6
GBM	ATP6V0A1 →	+0.501	+0.087	.001	<.001	3	5
BRCA	MCRIP2 →	+0.464	+0.070	<.001	<.001	3	5
BRCA	H6PD →	-0.327	-0.072	.005	<.001	3	5
LSCC	TNS2_S120 →	-0.393	-0.060	.002	.001	3	5
LSCC	XRCC6_T455 →	+0.497	+0.046	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060478 vs HSP90AA1_S231 — LSCC

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