Acrosomal vesicle exocytosis

Across TCGA cell cohorts, RNA activity of the Acrosomal vesicle exocytosis pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR48, HMGA2, and SOCS5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR48 grouped by Acrosomal vesicle exocytosis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	WDR48 →	+0.275	+1.313	.005	<.001	3	5
PANCREAS	HMGA2 →	+0.222	+0.937	.007	.004	3	5
SOFT_TISSUE	SOCS5 →	+0.160	+1.026	.006	.004	2	6
SOFT_TISSUE	POLR2I →	-0.246	-1.230	.004	.008	3	4
LIVER	SRSF2 →	+0.533	+1.447	.005	<.001	2	5
LARGE_INTESTINE	ABHD14B →	-0.142	-1.361	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR48 by Acrosomal vesicle exocytosis activity — SOFT_TISSUE

Explore this box plot interactively →