Prevention of polyspermy

Across TCGA patient cohorts, RNA activity of the Prevention of polyspermy pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLAT, IGFBP7, and CAVIN3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Prevention of polyspermy activity versus PLAT in BRCA (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLAT →	+1.199	+0.187	<.001	<.001	3	10
LSCC	IGFBP7 →	+0.567	+0.209	<.001	<.001	3	8
GBM	CAVIN3 →	+0.480	+0.108	<.001	<.001	3	8
BRCA	PPFIBP1 →	+0.367	+0.112	<.001	.001	3	8
UCEC	FILIP1L →	+0.803	+0.141	<.001	<.001	3	7
OV	ZCCHC24 →	+0.780	+0.146	.003	.001	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060468 vs PLAT — BRCA

Explore this scatter interactively →