Mammary gland morphogenesis

Across TCGA patient cohorts, RNA activity of the Mammary gland morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF280D, NEIL1, and ZNF34, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland morphogenesis activity versus ZNF280D in OV (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZNF280D →	+0.411	+0.926	<.001	<.001	3	4
OV	NEIL1 →	+0.672	+0.592	<.001	.003	3	4
BRCA	ZNF34 →	+0.438	+0.663	<.001	<.001	3	4
OV	RN7SL526P →	+0.739	+0.609	<.001	.002	3	4
COAD	EEF1AKMT4 →	-0.608	-0.527	<.001	.006	3	4
BRCA	HECTD2 →	+0.496	+0.451	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060443 vs ZNF280D — OV

Explore this scatter interactively →