Branching involved in prostate gland morphogenesis

pathway activity — cross-omics
GO:0060442Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Branching involved in prostate gland morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STXBP1, TLN2, and DCAF7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMSTXBP1 →+0.557+0.083.001.00237
BRCATLN2 →+0.544+0.085<.001.00136
HNSCDCAF7 →+0.220+0.068<.001.00136
BRCAPEBP1 →+0.484+0.097<.001<.00136
PDACLHPP →+0.482+0.079<.001.00136
GBMLRRFIP1 →-0.350-0.108<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration