Branching involved in prostate gland morphogenesis

pathway activity — cross-omics
GO:0060442Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Branching involved in prostate gland morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFRP1, ASPA, and MIS18A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVSFRP1 →+1.874+0.684<.001.00335
LUADASPA →+0.498+0.317<.001<.00134
LUADMIS18A →-0.450-0.180.001.00334
LUADCCL14 →+0.204+0.150.003.00334
LSCCSEMA6A-AS1 →+0.512+0.201.004.00334
PDACSEZ6L →+0.791+0.534<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration