Epithelial tube branching involved in lung morphogenesis

Across TCGA patient cohorts, RNA activity of the Epithelial tube branching involved in lung morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPN2, TBC1D2, and NUF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial tube branching involved in lung morphogenesis activity versus CAPN2 in UCEC (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CAPN2 →	+0.741	+0.165	<.001	<.001	3	5
UCEC	TBC1D2 →	+0.813	+0.133	.007	.001	3	5
UCEC	NUF2 →	-0.846	-0.132	.002	.001	3	4
LUAD	SKA1 →	-0.791	-0.482	.002	.007	3	4
OV	RAD51AP1 →	-0.671	-0.702	.007	.005	3	4
PDAC	FHL2 →	+0.473	+0.193	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060441 vs CAPN2 — UCEC

Explore this scatter interactively →