Epithelial tube branching involved in lung morphogenesis

Across TCGA cell cohorts, RNA activity of the Epithelial tube branching involved in lung morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AC15, PUSL1, and LPAR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H2AC15 grouped by Epithelial tube branching involved in lung morphogenesis-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	H2AC15 →	+0.975	+1.636	.009	<.001	3	4
LIVER	PUSL1 →	-1.376	-1.921	<.001	<.001	3	4
CNS	LPAR2 →	+0.891	+0.980	.003	.004	3	4
BLOOD_Myeloma	SDF4 →	-0.738	-1.443	.006	<.001	3	4
OESOPHAGUS	DCAF11 →	+1.053	+1.567	.001	<.001	3	4
OESOPHAGUS	PRR3 →	+1.158	+1.294	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H2AC15 by Epithelial tube branching involved in lung morphogenesis activity — URINARY_TRACT

Explore this box plot interactively →