Trachea morphogenesis

pathway activity — cross-omics
GO:0060439Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Trachea morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYTL4_S74, KIF5B, and RABEP1_S410, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCASYTL4_S74 →+0.859+0.059.003<.00134
LSCCKIF5B →+0.154+0.057.002.00234
GBMRABEP1_S410 →-0.213-0.060.005.00234
LUADSART3 →+0.142+0.051.002.00434
LUADPEX11A →-0.588-0.080<.001<.00125
BRCARFESD →+0.453+0.050<.001.00233
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration