Trachea morphogenesis

pathway activity — cross-omics
GO:0060439Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Trachea morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR3193, EDNRB, and PALMD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECMIR3193 →+1.372+0.167.002.00735
GBMEDNRB →+0.940+0.106.003.00634
CCRCCPALMD →+0.643+0.145.004.00534
COADTOP2A →-0.402-0.105.001.00434
COADRNVU1-30 →+0.679+0.142.002.00334
COADDEPDC1 →-0.638-0.100<.001.00634
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration