Bronchiole development

pathway activity — cross-omics
GO:0060435Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Bronchiole development pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRM2, CROCC, and AGO1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADRRM2 →+0.714+0.105<.001<.00137
UCECCROCC →-0.538-0.184.001<.00137
UCECAGO1 →-0.284-0.243<.001<.00137
BRCAERO1A →+0.764+0.147<.001<.00137
PDACCDCP1 →+0.392+0.068.001.00737
UCECACOT7 →+0.529+0.276<.001.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration