Bronchus development

pathway activity — cross-omics
GO:0060433Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Bronchus development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTTNBP2, KLF12, and PIK3IP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCTTNBP2 →+0.823+0.745.007.00134
HNSCKLF12 →+0.532+0.474<.001.00234
COADPIK3IP1 →+0.421+0.579.007.00233
UCECLRRN4CL →+0.640+0.435.003.00833
OVVMAC →+0.632+0.891<.001<.00133
LUADGARNL3 →+0.408+0.588.001.00533
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration