Positive regulation of heart growth

Across TCGA cell cohorts, RNA activity of the Positive regulation of heart growth pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIMS3, MMD2, and NOXA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RIMS3 grouped by Positive regulation of heart growth-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RIMS3 →	-0.369	-1.707	<.001	<.001	3	4
STOMACH	MMD2 →	+0.140	+1.487	.008	.001	3	3
STOMACH	NOXA1 →	+0.225	+1.310	.001	.009	3	3
BLOOD_Leukemia	MME →	-0.201	-0.670	<.001	.007	3	3
CNS	IL36RN →	-0.241	-1.209	.003	.003	2	4
CNS	STAT4 →	-0.258	-1.307	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RIMS3 by Positive regulation of heart growth activity — OVARY

Explore this box plot interactively →