Heart growth

Across TCGA patient cohorts, RNA activity of the Heart growth pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOJ, PLA2G5, and JAM3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart growth activity versus RHOJ in OV (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RHOJ →	+0.711	+0.887	.001	.002	2	7
BRCA	PLA2G5 →	+0.533	+0.778	.001	<.001	3	6
CCRCC	JAM3 →	+0.819	+0.828	.001	<.001	3	6
OV	C1QTNF1 →	+1.161	+1.044	<.001	<.001	3	6
CCRCC	SLIT3 →	+0.803	+0.748	.003	.002	3	6
OV	TSHZ3 →	+0.917	+1.000	.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060419 vs RHOJ — OV

Explore this scatter interactively →