Response to growth hormone

Across TCGA cell cohorts, RNA activity of the Response to growth hormone pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KMT2E, AP3M2, and STRIP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KMT2E grouped by Response to growth hormone-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KMT2E →	-0.717	-1.139	<.001	<.001	3	4
STOMACH	AP3M2 →	-1.216	-1.151	<.001	<.001	3	4
BREAST	STRIP1 →	-0.573	-0.538	.004	.002	3	4
STOMACH	UBQLN1 →	+0.490	+0.915	.006	.006	3	4
LARGE_INTESTINE	KLHDC10 →	-0.582	-1.054	.006	.001	3	3
LARGE_INTESTINE	AFF1 →	-0.969	-1.171	.002	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KMT2E by Response to growth hormone activity — SKIN

Explore this box plot interactively →