Aorta smooth muscle tissue morphogenesis

Across TCGA patient cohorts, RNA activity of the Aorta smooth muscle tissue morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNN1, LMOD1, and SYNPO2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aorta smooth muscle tissue morphogenesis activity versus CNN1 in UCEC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CNN1 →	+1.552	+0.230	<.001	.008	3	9
UCEC	LMOD1 →	+1.883	+0.459	<.001	.005	3	9
UCEC	SYNPO2 →	+1.647	+0.331	<.001	.007	3	9
UCEC	MYL9 →	+1.004	+0.275	<.001	.003	3	8
CCRCC	PDE1A →	+0.708	+0.896	<.001	<.001	3	8
OV	MRGPRF →	+0.551	+0.768	.006	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060414 vs CNN1 — UCEC

Explore this scatter interactively →