Atrial septum morphogenesis

Across TCGA patient cohorts, RNA activity of the Atrial septum morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RASAL2, CLINT1, and CEP170, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrial septum morphogenesis activity versus RASAL2 in HNSC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RASAL2 →	+0.256	+0.075	<.001	.001	3	6
OV	CLINT1 →	-0.261	-0.079	.001	.003	1	7
BRCA	CEP170 →	+0.191	+0.031	.003	.003	3	5
CCRCC	COL12A1 →	+0.755	+0.052	<.001	.006	3	5
BRCA	ENAH →	+0.249	+0.038	<.001	<.001	3	5
LSCC	MAP2_T1649 →	+1.332	+0.062	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060413 vs RASAL2 — HNSC

Explore this scatter interactively →