Atrial septum morphogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Atrial septum morphogenesis pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 15 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Atrial septum morphogenesis pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and UCS, show the opposite pattern, with higher activity associated with better survival.

ACC, COAD, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	III,IV	0.480	0.896	.001	72	view →
COAD	DFS	Quartile	IV	0.305	0.696	.003	43	view →
UVM	DFS	Median	III,IV	0.736	0.340	.002	42	view →
STAD	DFS	Median	II,III,IV	0.566	0.691	.004	40	view →
MESO	OS	Median	All	0.229	0.675	.002	27	view →
LIHC	OS	Median	III,IV	0.448	0.715	.010	21	view →
UCS	OS	Tertile	II,III,IV	0.661	0.263	.019	18	view →
CHOL	DFS	Quartile	II,III,IV	0.123	0.796	.024	17	view →
OV	OS	Quartile	II,III,IV	0.794	0.693	.011	16	view →
THYM	DFS	Median	III,IV	1.000	0.456	.006	16	view →
KIRP	OS	Quartile	All	0.961	0.719	.028	16	view →
GBM	DFS	Quartile	All	0.364	0.189	.014	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0060413–ACC (OS)

Open the ACC breakdown →