Atrial septum morphogenesis

Across TCGA patient cohorts, RNA activity of the Atrial septum morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO5, ESPL1, and KIF23, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrial septum morphogenesis activity versus FBXO5 in GBM (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FBXO5 →	+0.930	+0.470	<.001	<.001	3	7
BRCA	ESPL1 →	+0.844	+0.360	<.001	<.001	3	6
BRCA	KIF23 →	+0.691	+0.222	<.001	.005	3	6
GBM	MKI67 →	+1.007	+0.445	<.001	.002	3	6
GBM	KIF18B →	+1.057	+0.486	<.001	.001	3	6
LUAD	TACC3 →	+0.651	+0.390	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060413 vs FBXO5 — GBM

Explore this scatter interactively →