Atrial septum morphogenesis

Across TCGA cell cohorts, RNA activity of the Atrial septum morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPE, MYH10, and TGFB1I1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPE grouped by Atrial septum morphogenesis-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CPE →	-3.054	-1.280	.003	.009	3	4
UPPER_AERODIGESTIVE_TRACT	MYH10 →	-1.514	-0.808	.002	.004	3	4
STOMACH	TGFB1I1 →	-1.944	-1.116	<.001	<.001	3	4
STOMACH	RAB40A →	-0.472	-0.985	<.001	.002	3	4
OVARY	PSORS1C1 →	-1.375	-1.078	.008	.003	3	4
CNS	CD46 →	-0.540	-0.515	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPE by Atrial septum morphogenesis activity — SOFT_TISSUE

Explore this box plot interactively →