Ventricular septum morphogenesis

Across TCGA patient cohorts, RNA activity of the Ventricular septum morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMB1, CNPY4, and DNM1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular septum morphogenesis activity versus LAMB1 in OV (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LAMB1 →	+0.459	+0.045	<.001	<.001	3	9
UCEC	CNPY4 →	+0.535	+0.069	<.001	.003	3	9
BRCA	DNM1 →	+0.510	+0.051	<.001	<.001	3	9
BRCA	EIF2S2 →	-0.203	-0.031	<.001	<.001	3	9
BRCA	DPYSL3 →	+0.643	+0.048	<.001	<.001	3	8
OV	FHL3 →	+0.664	+0.063	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060412 vs LAMB1 — OV

Explore this scatter interactively →