Cardiac septum morphogenesis

Across TCGA patient cohorts, RNA activity of the Cardiac septum morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRG, ASXL1, and YPEL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac septum morphogenesis activity versus PTPRG in LSCC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PTPRG →	+0.718	+0.340	<.001	<.001	3	5
LSCC	ASXL1 →	+0.273	+0.215	.003	<.001	3	5
HNSC	YPEL1 →	+0.396	+0.296	.001	.004	3	4
LSCC	TPTEP1 →	+1.204	+0.293	<.001	<.001	3	4
LSCC	LRRC17 →	+0.723	+0.272	.003	.001	3	4
LSCC	LRCH2 →	+0.537	+0.226	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060411 vs PTPRG — LSCC

Explore this scatter interactively →