Cardiac septum morphogenesis

Across TCGA cell cohorts, RNA activity of the Cardiac septum morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMAD7, NRP1, and ITGAV, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac septum morphogenesis activity versus SMAD7 in BREAST (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SMAD7 →	+1.709	+0.084	.001	.004	2	13
BREAST	NRP1 →	+2.575	+0.088	<.001	<.001	3	12
BONE	ITGAV →	+1.277	+0.102	.001	<.001	3	11
BONE	GALNT1 →	+1.754	+0.093	.003	.002	3	11
BONE	ACVR1 →	+1.098	+0.106	<.001	.003	3	11
SOFT_TISSUE	TGFBR2 →	+2.332	+0.074	.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060411 vs SMAD7 — BREAST

Explore this scatter interactively →