Growth hormone receptor signaling pathway via JAK-STAT

Across TCGA patient cohorts, RNA activity of the Growth hormone receptor signaling pathway via JAK-STAT pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WAS, NCF1, and LILRB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Growth hormone receptor signaling pathway via JAK-STAT activity versus WAS in GBM (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WAS →	+0.709	+0.235	.001	<.001	3	6
GBM	NCF1 →	+0.520	+0.201	<.001	<.001	3	6
BRCA	LILRB2 →	+0.618	+0.324	.001	.001	3	6
GBM	HTRA4 →	+0.561	+0.169	.002	.001	3	6
LUAD	SLC17A9 →	+0.738	+0.139	<.001	<.001	3	5
GBM	STX11 →	+0.561	+0.204	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060397 vs WAS — GBM

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