Growth hormone receptor signaling pathway via JAK-STAT

Across TCGA cell cohorts, RNA activity of the Growth hormone receptor signaling pathway via JAK-STAT pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTBP2, ARL13B, and USP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTBP2 grouped by Growth hormone receptor signaling pathway via JAK-STAT-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PTBP2 →	+0.500	+1.039	<.001	<.001	3	5
OESOPHAGUS	ARL13B →	+1.139	+0.880	<.001	.001	3	5
STOMACH	USP1 →	+0.818	+1.491	.002	<.001	3	4
URINARY_TRACT	QSER1 →	+1.032	+1.930	<.001	<.001	3	4
URINARY_TRACT	POLD3 →	+1.013	+1.439	.002	.001	3	4
LIVER	MINDY4 →	+1.124	+1.412	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTBP2 by Growth hormone receptor signaling pathway via JAK-STAT activity — SKIN

Explore this box plot interactively →