Growth hormone receptor signaling pathway via JAK-STAT

Across TCGA cell cohorts, RNA activity of the Growth hormone receptor signaling pathway via JAK-STAT pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF1B2, SLC2A1, and CLPP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Growth hormone receptor signaling pathway via JAK-STAT activity versus EEF1B2 in OESOPHAGUS (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EEF1B2 →	-1.044	-1.070	.005	.002	3	6
PANCREAS	SLC2A1 →	+1.988	+1.359	<.001	<.001	3	6
OVARY	CLPP →	-1.017	-1.116	.001	.004	3	5
PANCREAS	SERPINH1 →	+1.210	+1.019	<.001	<.001	3	5
BREAST	PTPN1 →	+1.118	+1.068	.004	.001	2	6
LARGE_INTESTINE	NSMCE4A →	-0.581	-0.943	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060397 vs EEF1B2 — OESOPHAGUS

Explore this scatter interactively →