Regulation of DNA strand elongation

Across TCGA patient cohorts, RNA activity of the Regulation of DNA strand elongation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BIN3, COX4I1, and LAMTOR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA strand elongation activity versus BIN3 in LSCC (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BIN3 →	-0.240	-0.051	.001	<.001	3	4
UCEC	COX4I1 →	-0.552	-0.098	<.001	<.001	3	4
LSCC	LAMTOR1 →	-0.124	-0.042	.005	.001	3	4
GBM	TJP1_S329 →	-0.387	-0.035	.001	.002	3	4
HNSC	DPAGT1 →	-0.474	-0.057	.001	.007	3	4
HNSC	HM13 →	-0.400	-0.076	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060382 vs BIN3 — LSCC

Explore this scatter interactively →