Regulation of DNA strand elongation

Across TCGA patient cohorts, RNA activity of the Regulation of DNA strand elongation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V0D1, SH3BGRL3, and KIF1C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA strand elongation activity versus ATP6V0D1 in BRCA (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ATP6V0D1 →	-0.385	-0.172	.003	.002	3	4
HNSC	SH3BGRL3 →	-0.580	-0.230	.007	.001	3	4
LSCC	KIF1C →	-0.373	-0.212	.002	<.001	2	5
LSCC	IER3-AS1 →	-0.358	-0.148	.009	.007	3	4
OV	RPL34 →	+0.668	+0.175	.007	.009	3	4
OV	RPL32 →	+0.518	+0.166	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060382 vs ATP6V0D1 — BRCA

Explore this scatter interactively →