Regulation of DNA strand elongation

Across TCGA cell cohorts, RNA activity of the Regulation of DNA strand elongation pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSMC6, SKP1, and ANP32E, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA strand elongation activity versus PSMC6 in STOMACH (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PSMC6 →	+1.067	+0.317	.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	SKP1 →	+0.841	+0.246	<.001	<.001	3	17
LUNG_NSCLC_LUSC	ANP32E →	+2.070	+0.376	.002	.003	3	17
OVARY	RUVBL1 →	+0.891	+0.244	<.001	<.001	3	16
LUNG_SCLC	RUVBL2 →	+0.768	+0.207	<.001	.008	3	16
URINARY_TRACT	NUCKS1 →	+2.344	+0.432	.005	.006	2	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060382 vs PSMC6 — STOMACH

Explore this scatter interactively →