Regulation of atrial cardiac muscle cell membrane depolarization

Across TCGA patient cohorts, RNA activity of the Regulation of atrial cardiac muscle cell membrane depolarization pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAS7, SLC4A3, and LINC01128, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of atrial cardiac muscle cell membrane depolarization activity versus GAS7 in LUAD (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GAS7 →	+0.587	+0.181	<.001	.002	3	4
OV	SLC4A3 →	+1.183	+0.069	.005	.004	3	3
OV	LINC01128 →	+0.770	+0.069	.004	.004	3	3
OV	RN7SKP11 →	+1.233	+0.069	<.001	.004	3	3
GBM	PTGDS →	+1.095	+0.646	.009	.001	3	3
GBM	RASGRF2 →	+0.712	+0.962	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060371 vs GAS7 — LUAD

Explore this scatter interactively →