Regulation of Fc receptor mediated stimulatory signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of Fc receptor mediated stimulatory signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ID4, KEAP1, and HEMGN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ID4 grouped by Regulation of Fc receptor mediated stimulatory signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ID4 →	-0.263	-0.702	.005	.004	3	5
CNS	KEAP1 →	-0.465	-1.271	<.001	<.001	3	4
LUNG_NSCLC_LUAD	HEMGN →	+0.132	+1.006	<.001	<.001	3	4
URINARY_TRACT	RARB →	-0.150	-1.377	.009	<.001	3	3
STOMACH	SLC10A6 →	-0.213	-1.166	<.001	.001	2	4
STOMACH	METTL9 →	-0.226	-1.492	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ID4 by Regulation of Fc receptor mediated stimulatory signaling pathway activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →